Despite improvements in the mechanism of drug release, the treatment of brain tumors remains challenging. for that Now researchers are Increasing drug delivery for treatment of brain tumor.
A new study of processes that affect the entry of therapeutic agents into brain tumors. During the 178th meeting of the American Acoustic Society, he will present two strategies to increase therapy delivery.
For blood therapeutic agents to be effective, they must pass through blood vessel walls to reach enough number of cancer cells, Arvanitis researchers. But, tumors can affect their effectiveness in many ways.
Although tumors known to interfere with the blood-brain barrier, special blood vessel walls develop to protect the brain. The barrier structure is inconsistent, so the drug cannot be distributed within the tumor.
Unfortunately, increasing the dose to increase drug delivery is not possible because of side effects caused by drug interactions with healthy tissue, and the penetration of the drug into the tumor core remains limited.
To overcome this obstacle, new dosage forms of nanoparticles have proposed, which associated with lower toxicity and cleaning time, the researchers said. Despite progress, increasing the absorption of nanoparticles in brain tumors remains a major challenge.
By combining focused ultrasound methods with different nanoparticle compositions, researchers have investigated two strategies for increasing drug penetration in brain tumors.
One approach is the use of microbubbles to overcome blood vessel blockages in brain tumors and to increase the penetration of nanoparticles through the vessel wall.
The second method uses ultrasound in combination with temperature-sensitive nanoparticles. In this approach, ultrasound used to induce the release of drugs that encapsulated only in the tumor, thus increasing the efficacy of the drug.
Although these concepts have been around for some time, our mechanistic studies not only explain and prove the potential of combining focused ultrasound with various nanoparticle formulations for the treatment of brain tumors but also lay the foundation for more rational design and understanding. focused ultrasound treatment, researchers said.
Their findings suggest that this therapeutic strategy could provide a unique opportunity to increase nanoparticle delivery and its loading in the brain and brain microenvironment.