Scientists turn natural cellular processes into drug delivery systems, Scientists have developed new gene therapy techniques that convert human cells into large nanoparticle producers that filled with genetic material that has the potential to reverse the disease process.
Although this research designed as a proof of concept, experimental therapy slowed the growth of tumors and extended the survival of mice with glioma, which accounted for about 80 percent of malignant brain tumors in humans.
This new method based on a patented technology that encourages donated human cells as adult stem cells to spit out millions of exosomes which, after collected and purified, act as drug-containing nanocarriers. When injected into the blood, they know exactly where to find their target in the body, even if it’s in the brain.
This technology uses nanotechnology-based chips to transport biological loads to the skin. This action converts adult cells into all kinds of cells that are interesting for treatment in the patient’s own body.
Scientists place around 1 million donated cells (such as mesenchymal cells derived from human fat) on silicon-produced silicon plates and use electrical stimuli to inject synthetic DNA into donor cells.
As a result of the forced DNA delivery described by Lee, cells must dispose of unwanted material as part of DNA-transcribed stranded RNA and repair holes that have made in their membranes.
They killed two birds with one stone: they repaired cell membrane leakage and disposed of garbage, said, one researcher. The garbage bags they throw away are exosome. What excreted from cells is our medicine.
Electrical stimulation has the positive effect of multiplying thousands of therapeutic genes in a large number of exosomes released by cells, a sign that this technology can be measured to produce enough nanoparticles for human use.
This has the advantage of not having toxicity and not causing an immune response.
Tests on mice showed that labeled exosomes migrated to brain tumors and slowed their growth more often than substances used as controls.
Because of safe brain access to the exosome, Lee said the drug delivery system is promising for future applications in neurological diseases such as Alzheimer’s and Parkinson’s.