The researchers mapped malaria parasites that spread to human blood cells, Malaria parasites transform healthy red blood cells into dense versions of themselves that collect and make oxygen transport difficult.
Infectious diseases strike more than 200 million people worldwide and, according to the 2018 World Health Organization malaria report, cause nearly half a million deaths each year.
But so far, researchers have not understood exactly how the parasite effectively penetrates the red blood cell system. malaria parasites that spread to human.
The researchers focused on Plasmodium falciparum, the parasite that causes the most severe form of malaria. This parasite infects the host’s red blood cells, triggering the production of several proteins in the cytoplasm of the host cell, most of the cell mechanism and the fluid contained therein ultimately changes the physical shape of the cell.
This transformation not only causes cells to remain outside the body’s immune response, but also helps parasites to get to the cell surface and infect others. Together, proteins multiply parasites, leading to multiplication of malaria parasites.
So far, it is difficult to understand how the parasite works with the protein released because it is predicted that the parasite will export about 400 proteins. However, other research has found that proteins without specific genetic sequences can also be exported to the cytoplasm of cells.
They use very sensitive mass spectrometry to visualize proteins that interact with SBP1 during the proliferation process. This leads to the identification of several proteins specifically related to the transformation of host cells.
In this study, we developed an alternative approach to identifying exported proteins that are involved in the trade in complex and exporting parasitic proteins, the researchers said.
The SBP1 interactions identified in our study provide a powerful and invaluable platform for identifying extrinsic proteins associated with severe malaria caused by Plasmodium falciparum.
This study provides a comprehensive map of SBP1 interactions that reveal complex relationships and interactions between host proteins and parasites.
The results also pave the way for further investigation and discussion of the molecular mechanisms of infection that affect human red blood cells.