Proteins like snakes can wrangle DNA, It turns out that snake winding, often used as a symbol of medical knowledge, is more than enough. They also imitate the key to life itself. Biological Physics (CTBP) began an in-depth look at the dynamics of the major proteins that help DNA in chromosomes fold into functional and compact forms.
They found that the main protein coils also wrapped around each other and changed like snakes when they formed larger loops in DNA.
The loops in turn integrate DNA sites that regulate the transcription of genetic messages. Because the contours and functions are better understood, no one can carefully examine the condensin protein and cohesine that make up DNA. Proteins like snakes can wrangle DNA.
They found that this protein had a ring-shaped salmon consisting of two 35 nm rolls of protein. They end at one end on a pair of “head” motors connected to DNA coils and at the other end on “hinges” that should open and close to take strands.
Laboratory simulations show that this wound wound is not entangled.
This project is one of the biggest challenges to the group modeling method, which in this case combines the direct binding analysis (DCA) of the joint evolution of the sequence of proteins combined and the strength of atoms in proteins, which determine their shape and function.
To complement the structure with less evolutionary clues, this group uses the AWSEM algorithm developed by Wolynes and colleagues to determine the functional structure that is fully folded from a large number of atomic forces in a protein.
Using the same DCA approach in combination with structural simulations, we are now investigating condensation and cohesion that occur in humans. With this method, we can predict structures, but real force fields are needed to understand the details of their dynamics, Onucic said. Based on the structure originally planned, we conducted a simulation by AWSEM. This simulation shows entanglement
The models also show that the DNA-binding ATPase motor can change evenly.
The next step, researcher said, would be to test a larger double-stranded DNA system, a more realistic representation, to see if the turning was correct. These efforts will be part of a larger effort in the CTBP to extend the theory of protein folding to a much larger chromosome dynamics problem.
Researchers have indicated that this will be one of the main objectives of the Center’s work in the future.
This molecule, and how it stings in DNA, is a big part of many of the projects we do on chromosomes, researchers say.
There are many diseases that arise from chromosomal disorganization, and we want to better understand the mechanism of chromosome formation.