Identified pathways that extend lifespan by up to 500 percent, The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.
This study is based on the discovery of two main pathways that promote aging in C. elegans. This is a popular model in aging research because it shares many genes with humans and because of its short life span of only three to four weeks, scientists can act quickly to assess the impact of genetic and environmental influences on healthy life extension.
Because these pathways are preserved, which means that they have been transferred to humans through evolution, they have been intensively investigated.
A number of drugs are being developed to change healthy ways to prolong healthy life. Discovering synergistic effects opens the door to more effective anti-aging therapies.
The new study uses a double mutant in which the insulin pathway (IIS) and the TOR pathway are genetically modified. Because changes in the IIS pathway lead to a 100% increase in life and changes in the TOR pathway lead to a 30% increase, it is hoped that double mutants live 130% longer. Instead, the duration increased by 500 percent.
The effect is not one plus one equals two, but one plus one equals five. Our results show that nothing in nature exists in a vacuum; To develop the most effective anti-aging treatment, we need to examine longevity tissue, not individual pathways.
The discovery of synergistic interactions can lead to the use of combination therapy, each of which influences different ways of prolonging the lives of healthy people in the same way as combination therapy for the treatment of cancer and HIV.
Synergistic interactions can also explain why scientists have not identified a single gene that is responsible for the ability of some people to live at an unusual age without major age-related illnesses shortly before their death.
Over the past decade, the evidence gathered shows a causal relationship between mitochondrial dysregulation and aging. Future studies of Rollins will focus on further clarification of the role of mitochondria in aging, the researchers said.