Researchers found how bacteria kill themselves to fight viral infections, Researchers have discovered how the new immune system protects bacteria from bacteriophages (phages), viruses that specifically infect bacteria.
This new system is unusual in that it works through a failed infection, where infected bacterial cells damage themselves to prevent the infection from spreading to other cells.
This study provides new information that can be used to improve the treatment of multi-resistant bacterial infections by perfecting phage therapy or even by destroying self-targeted bacteria and how bacteria kill themselves to fight viral infections.
Abortion is an old concept, but still controversial – one bacterial cell basically takes one for the team and kills itself instead of using it to produce more phages. Discussed whether it is logical from an evolutionary point of view that unicellular organisms do this or not. However, if we consider bacteria as a cooperative community, as a biofilm and not as an individual cell, this makes sense.
Nearly 75,000 different bacteria have sequenced their genomes. Of these, Corbett said that the new defense system is around 10 percent.
The team deepened its research and continued to reveal a number of biochemical and structural details of the CBASS defense system, which contains a lot of protein.
They found that the HORMA protein understood the infection and then stimulated the second protein to synthesize the second messenger molecule. This molecule in turn activates the nuclear enzyme, which destroys the bacterial genome itself, kills cells and holds phages to multiply and infect other cells.
We only examined one of more than 6000 different CBASS systems, each of which encodes a different set of infection sensors that signal proteins and effector proteins such as nuclease in our system.
If we understand how these different parts work together and how bacteria mix and compare as they develop, we can get a more complete picture of how everything works and how we can get involved properly.