Neurons found in mice can affect effective diet medicines, You have eaten something, got sick and don’t want to eat this food again because it makes you feel that way.

This is because signals from the intestine to the brain cause this disease and cause dislike. Conventional wisdom causes a chain in the brain that presses food out of the stomach and makes you feel sick if you activate it too strongly. Eating part of your diet makes your body happy, even though it stimulates brain signals to stop eating, according to research.

Investigation of cell metabolism might find this second strand in mice. The researchers want to better understand which parts of the brain limit appetite and which neurons play a role in determining whether rats want to eat or not. The cerebellum, which suppresses appetite, is triggered by a type of neuron that contains calcitonin receptors (CALCR), which are located in the posterior structure of the brain called the medulla. Interestingly, these neurons do not have to be active in the brain so they do not suffer from the intestine to trigger an evil reaction. Neurons found in mice can affect effective diet medicines.

Because there are neurons that suppress nutrition but can also have disgusting effects, this must mean that there are various types of neurons or circuits in the brain that can stop eating with different emotional responses. When the researchers deactivated CALCR neurons, they were surprised to find other findings that contradicted the idea that the brain only controls nutrition and short-term consumption.

Exclusion of these neurons not only interferes with the suppression of nutrients by intestinal signals, but also leads to a continuous increase in food intake. Rats are obese, which shows that the brain stem system controls not only the amount of food but also the amount of food consumed in the long run.

This leads to a disposition to obesity because of an energy imbalance in mice (more inputs than outputs).

Likewise, the activation of CALCR neurons reduces rat food intake and body weight without causing disgusting bowel effects. In the study, the team found another neuron, CCK, which also reduces food intake and weight, but unlike CALCR neurons, causes an uncomfortable internal response. The difference between the two neurons lies in their circuit.

Neurons activate certain cells, CGRP cells, which cause this unpleasant feeling. In contrast to CCK, CALCR neurons are activated following the taste chain and activating non-CGRP cells, according to the researchers.

Obesity affects more than a third of the adult population in industrialized countries, which can cause diabetes or other serious long-term health conditions such as heart disease, explains Myers, who is also director of MDiabetes. Unfortunately, many diet drugs work, but they make people sick after taking it. Obesity remains a difficult condition for pharmaceutical management because treatment options have limited therapeutic benefits.

Drugs that contain CALCR and exclude CGRP can be very beneficial for overweight patients by suppressing nutrition and controlling food intake and weight in the long run. Researchers say: If we can find a drug for overweight people that suppress food intake and lead to long-term weight loss without negative side effects, it can really change someone’s life.

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