The ancient key to cell discovery for new cancer therapy, Australian researchers have discovered a metabolic system that can lead to new strategies for treating cancer therapy.
A team of medical researchers has found an association between yeast and mammalian metabolism that is essential for regulating cell growth and proliferation. The interesting thing about this yeast is that it changed evolutionarily around 350 million years ago, so you can question its discovery.
This is often called the body’s fuel gauge; A protein called AMP kinase or AMPK regulates cell energy and slows cell growth when they don’t have enough nutrients or energy to separate. The ancient key to cell discovery for new cancer therapy.
Another thing, namely a protein complex called mTORC1 / TORC1, which also regulates cell growth, increases cell proliferation when detecting high nutrient content such as amino acids, insulin or growth factors.
The hallmark of cancer cells is their ability to control this sensory system and maintain uncontrolled proliferation, the researchers said. At this stage, however, we have discovered a mechanism by which mTORC1 can also suppress and suppress AMPK.
The cells also divide smaller, indicating a disturbance in the normal regulation of cell growth, the researchers said. We measure the growth rate of mammalian cancer cells by depriving them of amino acids and energy (by depriving them of glucose) to mimic the conditions found in tumors.
Strangely, we found that this combined derivative actually increased the rate of growth that we found because cells entered “survival mode”.
In this mode, they eat themselves, so that the cells continue to grow even without adequate nutrition. It is important that this transition to survival mode disappears when we again eliminate the ability of mTORC1 to inhibit AMPK. These findings offer a new pathway for cancer treatment strategies aimed at suppressing cell proliferation in nutrient-poor tumor environments.