This discovery sheds new light on how cells move, When we cut our skin, groups of cells race to heal wounds. But this complex mechanism of collective cell movement.
The new recruitment between each cell and its neighbors makes it easy for researchers to find out what really moves them.
If we understand the underlying factors that cause cell migration, we might be able to develop new treatments to accelerate wound healing, the researchers said. now this discovery sheds new light on how cells move.
Notbohm and PhD student Aashrith Saraswathibhatla recently made a surprising discovery that shed new light on the emergence of this collective cell migration. Through experiments, they found that the strength of each cell is given to the surface below, in other words, adhesion is the dominant physical factor that controls the shape and movement of cells when cells move as a group.
Notbamm said that these unexpected findings provided new interpretations of newer theoretical models.
Researchers know that cell shape plays an important role in how they rearrange and migrate together.
For example, a circular cell that is packed together in a single layer cannot only exchange positions with neighboring cells. consider jamming side by side to a large crowd where it’s impossible to move. discovery sheds new light on how cells move.
On the other hand, cells with longer shapes can easily glide past their neighbors. These long and thin cells can be packaged in an endless configuration, making it very easy to rearrange them. This makes team movements easier.
Because elongated cells are larger, most computer models predict that the force at the edges of each cell is most important for determining its shape.
Notbohm and Saraswathibhatla began testing this theory in the laboratory.
His experiments used fluorescence imaging to evaluate the strength at the edges of each cell in one layer of epithelial cells, a type of cell that limits surfaces on the body such as the skin and blood vessels. They also place cells on the soft surface of the gel and analyze how the gel changes shape when cells migrate through the gel.
The gel test allows them to measure the level of adhesion or how strongly the cell is pulling the surface.
They also use chemicals to reduce or increase the strength produced by each cell and study the effects of these changes. Ultimately, according to the researchers, his experiments have shown that the strength that a cell exerts on its underlying surface basically influences its shape.
This is quite surprising because the key factors that influence cell size are below the cell. And now they can focus on what’s important. With a view to the interface between the substrate and cells, Notbohm hopes to make further progress in this field.
The good news is that the general phenomenon of the model is still true. This discovery only changes our understanding of theory.
This is very important because to develop possible new interventions to accelerate wound healing, you need to understand the main factors in cells that affect their shape and movement.