The huge genome of a small salamander may harbor the secrets of regeneration, The type of salamander called Axolotl looks like an alien with gills and wide eyes and has other global regenerative powers. Losing a limb, part of your heart, or even a large part of your brain? No problem: you grow back.
It regenerates almost everything after almost every injury that doesn’t kill, “the researcher said.
If scientists find a genetic basis for the ability to regenerate axolotl, they can find ways to repair damaged tissue in humans.
However, they were thwarted by the experience of another characteristic of Axolotl – it has the largest genome of all animals ordered so far and ten times the size of humans. The genome of a small salamander may harbor the secrets of regeneration Researchers said.
Blumen and colleagues have now found a brilliant way to bypass the complex genomes of animals and identify at least two genes involved in regeneration, eLife magazine reported on January 28. With the introduction of new gene sequencing and editing technology, researchers can compile a list of hundreds of candidate genes that can be responsible for regenerating limbs.
The enormous size of the axolotl genome, which is inhabited by a large area of several strands of DNA, makes it difficult to study the function of these genes.
This method allows them to identify two genes in the blastoma divider cell mass that forms at the location of the severed limb and is also responsible for partial regeneration of the axollot tail. Bunga stresses that there are more such genes. Due to the fact that humans have such genes, one day scientists might find out how they can be activated to accelerate wound healing or tissue regeneration.