New injection techniques can increase efforts to improve spinal cord, An international research team describes a new method of sending nerve progenitor (NSC) cells to spinal cord lesions in mice to reduce the risk of further injury and increase reproduction of cells that have the potential to repair.
NSCs have great potential for the treatment of various neurodegenerative diseases and spinal cord injuries. Stem cells have the ability to differentiate into many types of neuron cells depending on their environment.
As a result, there is great interest and effort in using these cells to repair spinal cord injuries and to effectively restore the functions associated with them, New injection techniques can increase efforts to improve spinal cord.
According to researchers, there is a risk of (further) damage to the spinal cord or intra-paremic bleeding.
This new technique is less invasive because the injected cells are inserted into the sub-spatial space of the spine between the crest membrane and the superficial layer of the spinal cord.
This injection technique allows a large number of cells to be distributed per injection, the researchers said.
Cells with proliferative properties, such as B. glial progenitor cells, then migrate to the spinal parenchyma and spread over time to several spinal segments as well as to the brain stem. The injected cell obtains functional property that matches the surrounding host cell.
And the researchers suggest that cells injected by sub-pillars tend to accelerate and increase the effectiveness of cell replacement therapy for several spinal neurodegenerative diseases where a large population of glial cells such as oligodendrocytes or astrocytes is desirable.
This could include spinal cord trauma, amyotrophic lateral sclerosis, and multiple sclerosis, the researchers said. injection techniques can increase efforts to improve spinal cord.
The researchers plan to test the cell delivery system in a larger preclinical animal model for spinal cord injury that better mimics human anatomy and size.
The aim is to determine the optimal cell dose and delivery time after a spinal cord injury, which is associated with the best treatment effect, the researchers said.