Reprogramming cells in their original state for regenerative medicine, Early development of mammals is a very complex process that involves complex and highly coordinated biological processes.
One such process is Zigotic Genome Activation (ZGA), which occurs after the connection of sperm cells and eggs marks the beginning of life. The initial embryos produced, called “zygotes”, are able to produce entire organisms, a property known as totipotence. the new reprogramming cells in their original state for regenerative medicine.
Totipotent cells are at the top of the development hierarchy and have the highest effectiveness of all cell types, which means that they have unlimited therapeutic potential.
Outside of pluripotent embryonic stem cells, which can only differ in all types of embryonic cells, totipotent zygotes lose their totipotence as when pluripotence ripens. Reprogramming cells in their original state for regenerative medicine.
Scientists have now found a way to manipulate pluripotent cells to reach the capacity of totipotent which is thought to only exist in zygotes.
This not only provides an overview of the emergence of totipotence and the earliest events in mammalian development, but also opens new doors for potential cell therapy that has not been investigated.
This study identified a factor that triggers totipotency, negative extension factor A (NELFA), which is capable of totipotent pluripotent embryonic stem cells in petri dishes. NELFA does this by deliberately changing the network’s regulation and cell metabolism.
In particular, NELFA can reactivate certain genes that are only active in zygote, but instead are silent in embryonic stem cells.
NELFA is also able to convert energy through pathways in potentially compound stem cells. All of these changes will produce a pluripotent stem cell that is converted to a state similar to totipotent.
The discovery of this method induces totipotency in cells outside the embryo also offers the possibility of building cells with maximum cellular plasticity for therapeutic purposes.
This increases the possibility of regenerative medicine applications, especially in cell replacement therapy.
A possible goal of this research is to translate the results into the development of a fast and effective strategy for reprogramming cells for clinical use, for example in the treatment of disabilities and developmental disorders.