Monitoring of Corona virus on bat with next generation sequencing, The researchers used Next Generation Sequences (NGS) to monitor how viruses like these multiply and develop in animal populations.
Routine and comprehensive monitoring with NGS can be expensive and time consuming. Less common virus markers may also be lost from the host sample. now the researchers Monitoring of Corona virus on bat with next generation sequencing.
These challenges have led geneticists to develop cheaper and more effective NGS-based strategies.
An international research group illustrates how enrichment – a new strategy for NGS – can be used to monitor corona viruses, especially those from bats. NGS is “enriched” with a probe (or bait), which is a small fragment of genetic material that finds and binds to viral DNA. This investigation provides a quick way to identify where viral genetic material can be hidden.
Coronavirus was identified by investigation in a clinical trial group, and the researchers reported that their approach also increased sensitivity and reduced sequencing costs.
We don’t want to explain that enrichment is a panacea for all NGS challenges, but in this case, I think this is a step in the right direction, say the researchers.
According to Wang, coronavirus is very important in bats to monitor it.
Many researchers believe that this virus has the potential to infect populations of other animals and even humans. The coronavirus that caused the fatal SARS outbreak or severe acute respiratory syndrome in 2003 was closely related to that found in bats and possibly from animal origin. Monitoring of Corona virus on bat with next generation sequencing.
The same is true for the virus behind the mysterious outbreak in January 2020 in Wuhan, China, and the acute pig diarrhea outbreak (UDF) in 2018.
Bats are also a well-known reservoir of Ebola virus, Marburg virus, Nipa virus, and Hendra virus, although they usually do not show symptoms.
The corona virus, especially those transmitted by bats, remains an important source of emerging infectious diseases, the researchers said. In the event that there is no outbreak, or what Wang calls “time for peace,” researchers can create a bank of current investigations that deals with known forms of the corona virus.
During outbreaks or “wartime”, they can use this information to track the development of viruses and spread of infections in animals and even human populations.
One of the challenges of using enriched NGS is that “you can only find viruses that you know about.
However, like all viruses, the bat coronavirus continues to change. If this approach is useful for monitoring and tracking outbreaks, inspection libraries need to be updated regularly, Researcher said. Successful NGS enrichment. We must treat our examination library as a living library. That will be our pursuit. He is optimistic that the work will produce results.