Complex processes of DNA repair have been discovered, Sophisticated filament systems, the dynamics of liquid droplets and protein compounds make it possible to repair some damaged DNA in the cell nucleus.
The results challenge the assumption that broken DNA hovers aimlessly and underscores the value of interdisciplinary research in biology and physics. Now the complex processes of DNA repair have been discovered.
DNA repair contributes to the stability of the genome, which allows cells to function in all organisms and promotes health.
DNA damage is very toxic to cells, and researchers have suggested for decades that this damage floats in the nucleus in an undirected direction to cause other cell changes or occur through fixation mechanisms.
The researchers then collaborated with U from space engineers to show that after a single pause, two strands of DNA migrate to be repaired through microtub long “automatic banks” such as filaments that also move. Complex processes of DNA repair have been discovered.
The researchers examined yeast cells with lots of DNA double-strand breaks and showed that coordination between shorter strands of microtubules and droplets like fluid from DNA repair proteins allowed for the formation and function of DNA centers. Researchers say: Liquid droplets work with intracellular microtubes to promote the accumulation of damaged DNA sites.
Protein repairs at these different sites are assembled into droplets, which combine into larger droplets to be repaired due to the shorter action of nuclear microtubules.
Then these larger oil droplets behave like spiders, Michael said, and burn with star-shaped filamentous tissue attached to a longer highway, where damaged DNA can be transported to DNA hospitals
Michael brought a video of Ashgriz droplets, which he projected onto the big screen in his office and confirmed that fluid dynamics seemed to be playing. However, communication in the biology-physics department is a challenge.
In the beginning, it was very difficult to understand what they were doing because our terminology was very different, the researchers said.
However, when the research team clearly described how the droplets behaved, this gradually made sense. After months of talking and experimenting, computer simulations repeatedly predicted that shorter filaments would move like pistons, lower the pressure in the nucleoplasm, and create a suction effect that would lead to fusion of droplets.
When we study in depth specific fields, we often part with each other, say researchers. Bringing people together from various perspectives can really increase understanding, and this work is a good example – thanks to Karim for his vision and initiative. The research team also revealed other important properties of these droplets. They rode droplets through many tests, bumping into each other and observing their behavior, which turned out to be very similar to Petri dishes and cells.
The most surprising finding came after several drop fusion cycles, the researchers found. It was very strange and completely unexpected, I still remember that day.
The team notes that larger droplets trigger concentration in the building blocks of filaments and force the creation of a type of self-locking brick pathway that allows DNA, along with nets, to attach to longer strands of the highway. According to Michael, the complicated process of seeing DNA damage points is easily missed, especially because the image is very automatic on the site.
Most software is made to see what is already seen.
We cannot rely on old observation methods, say researchers. We have to update our software and, if necessary, use a human eye view, which is controlled by simulation.