A clockwork mechanism that controls cell division in bacteria, Researchers at the Biozentrum Center at the University of Basel have discovered a “clock” mechanism that controls cell division in bacteria.
reports how small signaling molecules initiate “clocks” which inform cells of the appropriate playback time.
The ability of pathogens to multiply in the host is very important for the spread of infection. The degree of separation of bacteria is very dependent on environmental conditions. A clockwork mechanism that controls cell division in bacteria.
Under unfavorable conditions, such as B. Malnutrition, bacteria tend to stop after distribution and multiply more slowly. But how do bacteria know when it’s time to move on to the next round of cell division?
A team from Biozentrum from the University of Basel under the leadership of Prof. Urs Jennal has now identified a central switch for the reproduction of the Caulobacter crescentus model: the c-di-GMP signaling molecule.
How long the cell stops after division and how later it decides to take part in the next division round is still unclear. The c-di-GMP signaling molecule plays an important role in this regard.
Increased levels of c-di-GMP trigger individual gears from the cell clock one by one, the researchers explained. A clockwork mechanism that controls cell division in bacteria.
This gear is an enzyme called kinase. They prepare the cell transition from the resting phase to the division phase.
Under favorable living conditions, newborn bacteria begin to produce signaling molecules – these begin to beat. Initially, a low c-at GMP level activates the first kinase.
This activates the expression of more than 100 genes that direct cells to divide and increase c-di-GMP production.
The peak value that results from c-di-GMP finally stimulates the last wheel of the engine, also a kinase. “With this step, the cell finally decides to replicate its DNA and trigger cell division,” Genal explained.
At the same time, more than 100 genes are excluded again, because they are only important for the transition phase, but inhibit subsequent proliferation stages. A clockwork mechanism that controls cell division in bacteria.
The researchers found that the cellular kinase domain was initially fixed in a fixed position. The binding of c-di-GMP releases the domain, thereby activating kinases for gene expression.
The timing of the c-di-GMP regulation of the bacterial cell cycle by this signaling molecule appears to be a universal mechanism.
The researchers suspect that this mechanism allows bacteria to precisely coordinate growth and development.
Explanation of this new mechanism also contributes to a better understanding of the growth of pathogenic bacteria.