A new universal target for antiviral treatment, As the corona virus shows, viruses are a constant threat to humanity, Vaccines are developed regularly and given against certain viruses.
However, this process takes a long time, doesn’t help all those who need protection, and still leaves people exposed to new outbreaks and new viruses.
Now Massachusetts Hospital (MGH) researchers have launched new potential antiviral drug targets that could lead to treatments that prevent some infectious diseases that create general or universal treatments. The new universal target for antiviral treatment.
His work shows that the Argonaute 4 protein (AGO4) is the Achilles heel for viruses.
AGO4 belongs to the AGO protein family. So far there is little evidence why it is important.
Specifically, this protein is a unique antiviral in mammalian immune cells.
The group examined the antiviral effects of several argonavite proteins and found that only cells that lack AGO4 were “hypersensitive” to viral infections.
In other words, low AGO4 levels increase the likelihood of mammalian cells becoming infected.
MGH researchers suspect that increasing AGO4 levels can boost the immune system to protect it from various viruses.
The aim is to understand how our immune system works so that we can develop treatments that work against a number of viruses, not just certain vaccines, researchers say. new universal target for antiviral treatment.
Mammals have four argonaut proteins (1-4) which silence genes and are conserved in many living things, including plants.
These are RNAi and miRNA effector proteins, and RNAi is the most important antiviral defense strategy in plants and invertebrates.
Mice infected with flu show that animals with AGO4 deficiency have much higher levels of the virus.
The next step is to determine how broad the spectrum is for each type of virus, the researchers said.
Then we need to find out how we can improve AGO4 to increase protection against virus infections.