Group of antibiotics with a unique approach to attacking bacteria, A new group of antibiotics with a unique approach to attacking bacteria has been discovered, making it a promising clinical candidate in the fight against antibiotic resistance.
The newly discovered Corbomycin and the lesser-known compestatin have never seen a way to kill bacteria by blocking the function of bacterial cell walls. A new group of antibiotics with a unique approach to attacking bacteria has been discovered.
This discovery comes from a family of antibiotics called glycopeptides produced by soil bacteria.
Researchers have also shown mice that this new antibiotic can block infections caused by drug-resistant Staphylococcus aureus, a group of bacteria that can cause very serious infections.
Bacteria have walls around the outside of their cells that give them shape and are a source of strength, the researchers said. Antibiotics like penicillin kill bacteria by preventing wall buildup, but the antibiotics that we found actually work by doing the opposite and preventing the wall from collapsing. This is important for cell division. Group of antibiotics with a unique approach to attacking bacteria.
For cells to grow, cells must divide and expand. If you completely block the destruction of the wall, it will remain in prison and will not grow or grow.
When studying the genealogy of known glycopeptide members, the researchers examined the genes of people who did not have a known resistance mechanism with the idea that they could be antibiotics that showed various types of attacks on bacteria. “We assume that if the genes that make up these antibiotics are different, the way they kill bacteria might be different,” the researchers said.
The group confirmed that the bacterial wall is the site of this new antibiotic, using cell imaging techniques in collaboration with Yves Brunn and his team at the University of Montreal.
This approach can be applied to other antibiotics and help us find new antibiotics with different mechanisms of action.
Researchers say: We found a new antibiotic in this study, but since then we have found several more in the same family who have the same mechanism.