An unexpected view of the dynamic structure of the mitochondria, Mitochondria, such as electricity generation and energy storage, are important components of almost all cells in plants, fungi, and animals.
So far, it has been suggested that these functions underlie the static structure of the mitochondrial membrane.
Researchers at Heinrich Hein University in Düsseldorf (HHU) and the University of California at UCLA (UCLA), which are also supported by the HHU Center for Advanced Imaging (CAi), have now found that membranes in the mitochondria are not static at all and instead, they change Their structure in cells lives every few seconds. An unexpected view of the dynamic structure of the mitochondria.
This dynamic adjustment process further enhances the performance of our cell power plants. “From our perspective, these findings fundamentally change the way our cellular power plants work and are likely to change textbooks,” the researcher said. An unexpected view of the dynamic structure of the mitochondria.
Mitochondria are very important components in cells that perform important functions, including the conversion of energy from food into chemical energy in the form of ATP. ATP is the cellular energy currency and adults produce (and consume) about 75 kilograms of ATP per day. An unexpected view of the dynamic structure of the mitochondria.
ATP molecules are produced around 20,000 times a day and then used again for energy consumption.
This enormous ability to synthesize occurs in the inner membrane of the mitochondria, which has many folds, which is known as krista.
Previously, it was assumed that certain static crisis structures would allow ATP synthesis. It is not known whether and to what extent membranes can adapt or change dynamically in crises in living cells and which proteins are needed for this.
For the first time, the research team was able to show that membrane crises in living cells in the mitochondria are constantly changing their structure dynamically in seconds.
This suggests that membrane membrane dynamics require the recently identified protein complex, the MICOS complex. Damage to the MICOS complex can cause various serious diseases such as Parkinson’s disease and a form of mitochondrial encephalopathy with liver damage. An unexpected view of the dynamic structure of the mitochondria.
After identifying the first protein component of this complex (Fcj1 / Mic60) about ten years ago.
Our now published observations lead to the model that after membrane separation, the crystals exist as isolated vesicles in the mitochondria for a short time and then can reunite with the inner membrane.
According to researchers, this allows optimal and very rapid adaptation to the energy requirements of cells.