Physical tools help track various cancer cells diversity, Cancer cells are difficult opponents. One cause of this disease is due to the diversity of the cancer cell population before many possible treatments.
Researchers find it difficult to characterize and calculate this population.
The team led by Cornell uses a new interdisciplinary approach to analyze the behavior of breast tumor cells using statistical modeling techniques that are more widely used in physics and economics. Physical tools help track various cancer cells diversity.
The team was able to show how the diversity or heterogeneity of cancer cells can be influenced by their chemical environment, namely through interactions with specific proteins that lead to tumor growth.
A research team is working with CNF to develop this microfluidic chip with four identical three-channel devices.
The team inserted breast tumor cells and CCL19 chemokine protein into each device and then analyzed the behavior of cancer cells using open source software.
Quite difficult to treat cancer. Many people in this region believe that this is caused by the diversity of the cancer population, the researchers said. While immune cells are round and similar and move the same way, cancer cells are formed differently and move at different speeds. Physical tools help track various cancer cells diversity.
Another challenge is that only a few cancer cells move quickly and are most damaging. They are hard to find.
The effort to trace these rare cells is similar to the search for elusive particles in the laboratory of co-author Anders Reid, professor of physics at the College of Arts and Sciences.
During a coffee conversation, cancer cell research can include the same type of sophisticated statistical tools that particle physicists use to understand the rare energy phenomenon like the Higgs boss they are looking for.
What we do in particle physics is statistical analysis of data to find out what functional forms our data describe, researchers say. Here too, his interest is to see and characterize people who have migrated further. Many of the tools we use in particle physics are very suitable for this analysis. Physical tools help track various cancer cells diversity.
The team introduced breast tumor cells together with the CCL19 chemokine protein into the device, which is secreted by lymph nodes and is highly expressed in malignant tumor cells.
To model the trajectory of cancer cells, the team used Root, open source software for statistical analysis in high energy physics and in several economic applications.
Researchers have found that the presence of chemokines causes the target cancer cells to move faster and increase heterogeneity.
Treatment that blocks the CCL19 receptor can reduce tumor cell invasiveness, but can also cause cancer cells to use new and stronger survival strategies.
Wu’s team analyzed how these cells respond to environmental signals such as chemical gradients, temperature, light intensity, and mechanical strength, and hope to clarify basic biological principles that are not cut and dried like the basic laws of physics. Physical tools help track various cancer cells diversity.
There are already many tools in physics because physics has always been a very quantitative field, researchers say.
Quantitative biology has just formed. I think this integration is very powerful because you don’t need to reinvent the wheel for this modeling.