A promising new strategy that will help broken bones heal faster, People with diabetes have a higher risk of fracture bone than the general population. And if they destroy you, healing will take longer than usual.
In the March issue of Biomaterials, Henry Daniel, Shuing (Sherry) Ian, and his colleagues at Pen Dental share promising results from animal models in which herbal medicines accelerate fracture healing.
Working with Insulin-like Growth Factor-1 (IGF-1) Proteins has shown that orally resistant drugs delivered to shelves planted in lettuce can stimulate bone marrow cell growth and encourage bone regeneration. A promising new strategy that will help broken bones heal faster.
This drug for patients with fracture diabetes requires repeated injections and hospitalization. As a result, patient compliance is low. Here we give oral medicine once a day and we see that the healing is very accelerated.
Healing fractures is an important health problem, especially for patients with diabetes, said researcher. “They tend to reduce bone repair and increase the risk of fractures, which is a treatment challenge. While giving IGF-1 this new human is effective, easy to administer, and an attractive choice for patients. A promising new strategy that will help broken bones heal faster.
This study offers new and ideal treatment options for diabetes fractures and other musculoskeletal disorders.
This research uses a platform for making herbal medicines that Daniel has developed over the years. This results in the introduction of proteins that are attracted to plant cells which causes them to express and ultimately produce this gene in their cells. This protein in its leaves can be collected and used in oral therapy.
In this case, the aim is the new IGF-1, a protein that is important for healthy bones and muscles. It is known that lower IGF-1 levels in the blood are associated with an increased risk of fracture.
Based on previous research on muscular dystrophy, which was conducted with former faculty member at Penn Elizabeth Faculty of Dentistry at the University of Florida, the researchers believe that the specific form of IGF is a precursor to a protein that contains a separate component known as E peptide which tends to stimulate regeneration better than IGF -1 adult who has no peptides. This IGF1, which is used in clinics, not only lacks e-peptide, but is also a glycosylation, an inactive form. A promising new strategy that will help broken bones heal faster.
The team used Daniel’s improved method to express the human version of IGF-1 in plant leaves and to eliminate antibiotic resistance genes used to select plants that grow target proteins. This is an important step to prepare therapy for clinical use.
They combine IGF-1 precursor protein with another protein, CTB, which helps transfer fusion protein from the digestive tract into the bloodstream.
After growing GMO lettuce plants, they freeze and clean the leaves, which confirms that the product has been stable for almost three years.
What is fundamental to all these projects is that we want to make the delivery of these drugs affordable, comfortable and possible at home,Researcher said.
In mouse and human cells, researchers have shown that drugs made from plants cause different cell types, including cells for oral tissue and osteoblasts or bone-forming cells, to grow and differentiate or form many different cell types. A promising new strategy that will help broken bones heal faster.
After further studies of drug activity in animal models, the researchers first showed that feeding rats with plant products led to an increase in IGF-1 levels.
Finally, in the diabetic mouse model, they found that feeding animals increased bone volume, density, and area, which was a sign of a healthier healing process. A promising new strategy that will help broken bones heal faster.
“We hope to find a partner to continue this work because there are many people with diabetes who can benefit from the therapy,” Daniel said. In their future work, the researchers hope to further develop IGF-1 which plants plants to bring it to the clinic not only for the treatment of fractures, but also for other musculoskeletal problems, including osteoporosis and bone regeneration after cancer.