Researchers identified proteins in parasites that cause fatal diseases, To develop more effective methods for the treatment of parasitic diseases such as African sleeping sickness, Chagas disease and leishmaniasis, scientists are looking for weaknesses in the molecular machinery of organisms.
This weakness can then be directed to drug therapy to kill parasites.
Even though they have made significant progress in recent years, scientists are still trying to find out how complex parasitic molecular systems work.
A research team recently contributed to this understanding by discovering the function of certain proteins in three parasites related to Trypanosama brucei, Trypanosoma cruzi and Leishmania, which spawn millions of people with sometimes deadly diseases throughout the world. Researchers identified proteins in parasites that cause fatal diseases.
According to Meredith Morris, professor of genetics and biochemistry, parasites have the same molecular arrangement as humans. Therefore, drugs that can kill parasites often cause dangerous or dangerous side effects to human hosts. We are always looking for ways to distinguish parasites from us, researchers say.
One of the main differences is that parasites have special cell compartments or organelles, which are essential for their survival. Morris and his team reported the results to mSphere on February 19, 2020. The title of the report was “Trypanosoma brucei Pex13.2 is an accessory peroxin that functions when importing PTS2 protein and is located in the glycosome subdomain.” Researchers identified proteins in parasites that cause fatal diseases.
These parasitic special organelles are called glycosomes, which play an important role in cellular processes, especially in energy metabolism.
The glycosome organelle is surrounded by a single membrane that contains several proteins. This protein (Pex13.1, 13.2 and 14) imports other proteins needed for normal cell function.
In their study, Morris and his students used a biochemical approach to partially complete the composition of these three glycosome proteins. They showed that Pex13.2 is an integral glycosomal membrane protein that interacts with Pex13.1 and Pex14, which were previously unknown. Researchers identified proteins in parasites that cause fatal diseases.
With the advanced imaging technology in the Light Imaging Facility, they also received high resolution images and found that Pex13.2 has a unique localization model that can be very important for its function.
The team also silenced Pex13.2, which produces parasites with smaller and larger glycosomes. Without 13.2, the parasite will not be able to import glycososome proteins, which will cause parasite death. Others have shown that cells die when 13.2 is turned off. Researchers note that one day pharmaceutical companies can develop a rational approach to disrupting systems and killing parasites if they fully understand the parts and functions of organelles.