The New cell in the immune system with Jekyll and Hyde properties, Scientists have identified rare new cells in the immune system with “Jekyll and Hyde properties”.
These cells play an important protective role in immunity to infection, but if not regulated, they also mediate tissue damage in autoimmune diseases.
The immune system controls infection by using various immune cells, such as T cells, to respond to and control invading germs.
However, if these immune cells are not tightly regulated, they can attack and damage body tissues, which leads to the development of autoimmune diseases.
The molecule, known as a T cell receptor (TCR), allows T cells to recognize infectious agent components with very good specificity. TCR allows T cells to respond and ultimately eliminate the infectious agent. .The New cell in the immune system with Jekyll and Hyde properties
So far, scientists have assumed that there are two different T cell populations that express TCR ‘α’ or ‘γδ’. Aβ is the most common T cell in the body.
They play a key role in remembering previous infections or immunizations, helping us protect ourselves from recurrent infections and providing vaccines that create protective immunity.
This is more common on mucosal surfaces such as the lungs or intestine and offers a direct first line of defense against pathogens that penetrate this pathway.
We have found new cell types that express αβ and γδ TCR. This rare population of chimeric or hybrid αβ-γδ-T cells has αβ and γδ-T cell properties. It is important that they are usually very activated and can act as first aid for controlling bacterial infections. The New cell in the immune system with Jekyll and Hyde properties
However, given this high level of activation, they are effectively “Jekyll and Hyde cells” because they can also trigger autoimmune reactions in certain contexts.
Using an infection model with Staphylococcus aureus, Professor Mills and his team found that these cells rapidly mobilize during infection and play a key role in removing germs from the body quickly.
Therefore, the induction of hybrid αβ-γδ-T cells can represent a new approach to developing vaccines that are more effective against Staph aureus and other infectious diseases, while increasing our ability to control their response can offer additional therapeutic options. The New cell in the immune system with Jekyll and Hyde properties.
Therefore this approach to inhibit highly active immune cells in susceptible individuals can open new approaches for the treatment of autoimmune diseases such as psoriasis and multiple sclerosis.