How our immune system deals with fungal and viral infections, The body’s immune response to fungal infections changes when the patient is also infected with a virus. This emerged from a new study in which both types of infections were examined together for the first time.
Fungal infections are the main cause in patients with immune disorders, such as B. patients with AIDS recipients or transplant recipients, but usually occur with secondary viral infections.
Although doctors understand how the immune system responds to each of these types of pathogens, less is known about what happens when both occur together.
White blood cells usually attack pathogens through a process called phagocytosis, in which pathogens are taken by white blood cells.
However, with fungal infections, this process sometimes “reverses” the expulsion of fungi from white blood cells through a process called “erythocytosis”. How our immune system deals with fungal and viral infections.
The team uses sophisticated microscopy techniques to examine living white blood cells exposed to two types of viruses, HIV and measles, along with the fungal pathogen Cryptococcus neoformans. This opportunistic pathogen is very deadly in HIV + patients, where it causes around 200,000 deaths every year worldwide.
Researchers have found that white blood cells emit fungal cells much faster than not being able to deal with it.
Because both are caused by viruses, the two researchers concluded that their effects tended to be a common response to viral coinfection.
Researchers say: This is the first time scientists have studied the response of our immune system to fungal infections in environments that are far more realistic than secondary (viral) infections. We don’t yet know whether this mechanism makes white blood cells more or less effective in fighting infection. How our immune system deals with fungal and viral infections.
Although removing the fungus cells releases macrophages to attack the virus, it also releases fungal cells to continue to spread throughout the body.
Studying this process in animal models will be the next step for the team, with the long-term goal of using the mechanism used to remove the fungus and use it to eliminate these pathogens from the body.