Researchers recently proved the ability to grow human blood vessels in pig, A team of researchers recently proved the ability to grow human-derived blood vessels in a pig a novel approach that has the potential for providing unlimited human vessels for transplant purposes.
Because these vessels were made with patient-derived skin cells, they are less likely to be rejected by the recipient, helping patients potentially avoid the need for life-long, anti-rejection drugs.
There’s so many chronic and terminal diseases, and many people are not able to participate in organ transplantation.
About 98 percent of people are not going to be eligible for a heart transplant, so there’s been a huge effort in trying to come up with strategies to increase the donor pool. Researchers recently proved the ability to grow human blood vessels in pig.
Because of similarities between human and pig physiology, scientists have historically studied pigs to discover treatments for health issues, including diabetes.
Before researchers engineered human insulin, doctors treated patients with pig insulin.
This could allow us to make organs with human blood vessels that would be less apt to be rejected and could be used in patients in need of a transplant. That’s what typically causes rejection the lining of the blood vessels in the organs.
The blood vessels created by the Garry duo will avoid rejection because of the method by which they are made.
The team injects human-induced pluripotent stem cells taken from mature cells scraped from a patient’s skin and reprogrammed to a stem cell stateinto a pig embryo, which is then placed into a surrogate pig.
In the future, viable piglets, with blood vessels that will be an exact match to the patient, will ensure a successful transplant and the ability to live without the need for immunosuppression, or anti-rejection, drugs.
There’s hundreds of thousands of patients that have peripheral artery disease, either because of smoking or diabetes or any number of causes, and they have limb amputations.
These blood vessels would be engineered and could be utilized in these patients to prevent those kinds of life-long handicaps, if you will. Researchers recently proved the ability to grow human blood vessels in pig.
The first phase of their study, approved by the U of M’s Stem Cell Research Oversight committee, brought the first embryo to a 27-day term.
Because of the success of this phase, Researchers are currently seeking the committee’s approval to advance the research further into the later gestational period.
Researcher said, While it is a first phase, there’s pretty solid proof of concept. We believe that we’ve proven that there’s no off-target effects of these cells, so we’re ready to move forward to later gestational stages.