The project could aid efforts to detect and prevent the spread of coronavirus, With the increasing number of Covid-19 cases in the United States and around the world, the need for quick and easy-to-use diagnostic tests is becoming increasingly urgent.
The MIT-based startup is currently working on a paper test that can produce results in less than half an hour based on technology developed by the MIT Institute for Medical Technology and Science (IMES).
Elsewhere at MIT, several other research groups are working on projects that can help scientists better understand how coronaviruses are transmitted and how infections can be prevented.
His work covers areas ranging from diagnosis and vaccine development to more traditional disease prevention measures such as social distance and hand washing.
Researchers have used this technology, known as side-stream technology, to make tests for the Ebola virus, dengue fever, and Zika, among others.
The test consists of pieces of paper coated with antibodies that bind to certain viral proteins.
The second antibody is bound to gold nanoparticles and the patient sample is added to the solution of these particles. The test strips are then soaked in this solution. The project could aid efforts to detect and prevent the spread of coronavirus.
If the viral protein is present, it binds to antibodies on the paper tape and antibodies that are bound to the nanoparticles, and within 20 minutes a colored spot appears on the tape.
At present there are two main types of diagnosis of Covid-19.
Such a test checks a patient’s blood sample for antibodies to the virus. However, antibodies are often only detected a few days after symptoms appear.
Another type of test looks for viral DNA in mucus samples. These tests can detect viruses early in infection, but require polymerase chain reaction (PCR), a technology that increases the amount of DNA to detectable levels and takes several hours to complete.
Traditional vaccines consist of an inactive form of viral protein that triggers an immune response.
However, this vaccine usually takes a long time and is too risky for several diseases.
A vaccine made from messenger RNA is an interesting alternative because it causes the host cells to produce many copies of the encoded protein, which causes a stronger immune response than the protein that is supplied by itself.
The RNA vaccine can also be quickly reprogrammed to target various viral proteins as long as the protein coding sequence is known.
Messenger RNA can encode virus antigens, but to work we need to find ways to send these antigens to the right side of the body so they can be expressed and produce an immune response.
We also need to ensure that vaccines provide adequate immune stimulation to get a strong response, “Anderson said.
On average, their experiments showed that coughing can send droplets of up to 13 to 16 feet, while sneezing can throw them up to 26 feet.
Ambient air conditions can cause the remaining droplets to be further distributed to the top level at the company’s location.
“This virus will stay with us for a while, and the data certainly shows that it will not disappear suddenly as time changes,” he said.
There is a good and important balance between safety, preventive action and action, which is important to enable research now and to accelerate it drastically so that we can be better prepared and informed about the steps in the coming weeks, the months when the worst happens. revealed The project could aid efforts to detect and prevent the spread of coronavirus.
Another great way to protect yourself from all these infectious little droplets is hand washing. (Again and again and again.)
In addition, we simulate various airport hand hygiene strategies above travel restrictions to offer an optimal strategy that combines travel restrictions and improved hand hygiene to reduce Covid-19 progress such as in the short term (week) and long term (next flu season).
Juanes said that they would immediately provide the results through MedarXiv while the work followed peer review in the magazine.
This will allow information to reach other academic and government institutions in a timely manner, he said.