Building and testing of a computer generated bacterial genome, All organisms on our planet keep a blueprint of life molecules in the DNA code in their genomes.
The digital revolution in biology, driven by DNA sequencing, allows us to read the genomes of various germs and multicellular organisms that live in our world.
At present, DNA sequences of more than 200,000 microbial genomes are stored in digital genome databases and expand our understanding of how DNA systems in living systems exponentially. Building and testing of a computer generated bacterial genome.
With the extraordinary treasure of these molecular building blocks, bioengineers learn to read (sort) and write (using chemical synthesis) long DNA molecules and reproduce useful germs using computers.
The laboratory also uses synthetic biological systems and approaches to identify key genes in species that function as genetic components for the formation of microbial genomes for application in chemistry, medicine and sustainable agriculture.
The research team physically produced Caulobacter ethensis-2.0, the first fully produced computer genome in the world. Based on natural freshwater bacteria, the researchers calculated DNA sequences that were ideal for chemical production and the construction of a reduced genome that consisted only of basic functions. Building and testing of a computer generated bacterial genome.
During the design process, more than one-sixth of all 800,000 letters of DNA in the artificial genome were replaced, and the entire genome was made as a large circular DNA molecule.
While living cells do not yet exist, gene function has been tested throughout the genome design.
In this experiment, the researchers found that around 580 of the 680 functional genes, showed the promise of an approach to design genome production.
During the AAAS 2020 session “Synthetic Biology: Digital Design of Living Systems” (February 14, 2020, 3:30 PM PST), Christians will discuss the possibility of using synthetic genomes in the future for industrial and health purposes.
He will also talk about the need for in-depth discussions in the community about the challenges and objectives of using this technology, and at the same time how to prevent potential abuse.