A new study from researchers at the University of Illinois shows that three phenolic compounds in the skin of cocoa beans have a strong impact on fat levels and immune cells in mice can turn into chronic inflammation and obesity related to insulin resistance.

Visiting scientists found in the food sciences Miguel Rebollo Ernants and Elvira Gonzalez in December Medjani, a professor in the department that cocoa husk contains three high-level beneficial bioactive chemicals found in cacao, epicatechin and procyanidin B2 coffee and green tea. Rebollo Hernanz produces runny base extracts of extract containing these compounds, and tests their effects on the mast cells of the lungs, called adipocytes and immune macrophages called cells.

Using computer modeling and bioinformation techniques, he also studied the effects of each phenol on cells individually.

The aim of this study is to investigate whether bioactive compounds in cocoa shells are effective against inflammatory macrophage cells in eliminating or reducing inflammation biomarkers, “Casa de Whelk, also director of nutrition science. If phenol in extracts block mitochondrial fat cells or reduce damage and prevent insulin resistance. Like a battery in a cell that burns fat and glucose to produce energy, mitochondria can be damaged if the body shows fat levels, glucose and high inflammation of Casa de Medjani.

When researchers treat adipocytes separately with water extracts or three phenolic compounds, damaged mitochondria in the cells are repaired and in adipocytes accumulate less fat, inhibit inflammation, and restore cell insulin sensitivity.

Scientists recently reported their findings in an article in the journal Molecular Nutrition and Food Research. When adipocytes accumulate too much fat, they increase macrophage growth. This starts a toxic cycle in which adipocytes and macrophages secrete poisons that interact with fat burning, de Medjani said.

Over time, this chronic inflammation reduces the ability of cells to take glucose, which leads to insulin resistance, and can improve type 2 diabetes because blood glucose levels increase. To simulate the inflammatory process that occurs in the body when macrophages and adipocytes begin to dance poisonously, Rebollo-Hernanz increases adipocytes to be a solution where they breed macrophages.

Then we observed that this inflammatory disease is increasing in the solution of oxidative damage from mitochondrial fat cells.Fewer mitochondria are found in adipocytes, which are stored in solution, and the mitochondria in these cells are damaged, he found. When the researchers treated phenol extracts of adipocytes, adipocytes undergo a process called chocolate, where they change, which is converted by white fat cells in another form called creamy adipocytes.Creamy adipocytes are a special form of fat with higher mitochondria and increased fat burning efficiency.


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