So far, research has used stem cells taken from patients or donors and injected into the patient’s heart to regenerate damaged tissue and lift it with promising results.
While the next generation of cell therapies is on the horizon, significant challenges remain in the context of stem cell distribution.
A high blood supply to the heart, combined with various tissues that are joined together, by which circulating cells are contacted, this means that most stem cells in the lungs and spleen are completed.
Now researchers at the School of Cellular and Molecular Medicine in Bristol have found a way to overcome them by modifying stem cells with special proteins, making them “home” to heart tissue.
Dr. Adam Perriman, lead author, assistant professor of biomaterials, Ukri Future Leaders Fellow and founder of the CytoSeek Cell Therapy Technology team, explained through regenerative cell therapy that someone would try to treat after myocardial cells rarely go there. Our goal is to use this technology to re-engineer cell membranes, so that when injected, they will use a certain network of our choice.
We know that some bacterial cells contain properties that allow them to recognize and live in diseased tissues. For example, mouth bacteria in our mouth can sometimes cause throat infections. When it enters the bloodstream, it can enter damaged heart tissue and cause infective endocarditis. Our goal is to reproduce the ability to target bacterial cells themselves and apply them to stem cells.
The team has developed technology by studying how bacterial cells use proteins called adhese to “house” heart tissue. With this theory, researchers were able to produce a compound cell membrane version that could be “painted” outside the stem cell. In animal models, the team that showed this new technique was able to modify cells by directing stem cells to the heart using a mouse.
Dr. Added to Perriman Our results show that heart characteristics of infectious bacteria can be transferred to human stem cells. It should be noted that in the mouse model that the adhesin protein designer spontaneously enters into the plasma membrane of stem cells without cytotoxicity and then modified cells enter the heart. transplantatsiyata. Za, this is the first time the targeting properties of infectious bacteria are transmitted to mammalian cells.