The human body holds rich and complex microbial communities, especially in the skin, in the mucous membranes of the mouth and digestive tract and has a fundamental role in health and disease.
In particular, the skin is colonized by a large number of microorganisms. is. with a stable species composition over time. Skin related diseases such as psoriasis, eczema, acne, vulgaris or dandruff are associated with strong and specific changes in the microbiome.
Targeted human microbial manipulation can be a potential therapeutic strategy for treatment and disease studies.
The most important example of this is the treatment of antibiotic-resistant bacteria Clostridium difficile in microbial gut with fecal transplantation. Likewise, microbial manipulation of the skin promises a new therapeutic strategy for skin diseases.
Skin microbial manipulation promises new therapeutic strategies for skin diseases. We are very interested in Cutibacterium acnes and its many types, because these bacteria are an important part of microbiological human skin and some types are associated with variations in microbiomes, which are likely to cause acne vulgaris, said Mark Guell head of the Translational Synthetic Biology group in the Science Department Experimental and Health (DCEXS). That’s why we developed and tested an approach to modulating the subpopulation of this species at the strain level Guell added.
For this study, the researchers prepared a probiotic solution from donor microbes and applied it to 18 healthy volunteers aged 22 to 42 years.
Eight different skin areas – in the chest and along the spine – are intended for use and are chosen because of the usually high percentage of sebaceous glands.
After a few weeks, the microbial skin returned to the baseline and no side effects were noted. They show that after sequential use of donor microbes, the recipient becomes more similar to the donor microbes. The success rate depends on the composition of the recipient and the donor microbiomy as well as the bacterial burden applied.